DIABETES INSIPIDUS:

DIABETES INSIPIDUS:

There is disturbance in renal concentrating mechanism, resulting in polyuria nad inability to produce hypertonic urine. DI is due to absence of an ADH effect, either because of impaired or failed secretion (cranial or central DI) or lack of end organ response to ADH (nephrogenic DI). Most of the inherited nephrogenic DI have mutation in ADH V₂ receptor, there is also down regulation of AQP2 in acquired forms of DI.