Diabetic
tissue damage includes microvascular complications (retinopathy and
nephropathy) and macrovascular complications (ischaemic heart disease, vascular
disease, stroke and renal artery stenosis) and neuropathies. Microvascular
tissue damage is the results of hyperglycaemia per se. Macrovascular
complications are found to be associated with insulin-resistant states and hyperinsulinaemia.
Due to these complications diabetes is also a most frequent cause of blindness
and cardiovascular disease. Few cells types are vulnerable to direct damage
from chronic hyperglycemia, for e.g. mesangial cells of kidney, vascular
endothelial cells, pancreatic beta cells, Schwann cells and neurons.
This blog is useful for all who is concerned with Biochemistry.
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