|Fig. Megaloblastic anemia showing megaloblastics cells|
An increased MCV can be due to a number of reasons but careful review of the patient's history and blood smear can narrow the diagnostic possibilities. The differential can be divided into two broad categories based on RBC morphology.
Round macrocytosis-due to abnormal lipid composition of the erythrocyte membrane. Common etiologies include:
2. Liver Disease.
3. Renal Disease.
4. Hypothyroidism ("myxedema of the red cell").